When we are trying to process the 997 Message over As2 Protocol to the one of partner, we got the below issue.

Retrieving the COM class factory for component with CLSID {254B4003-2AA7-4C82-BB2E-18BA7F22DCD2} failed due to the following error: 80040154 Class not registered (Exception from HRESULT: 0x80040154 (REGDB_E_CLASSNOTREG)).

After troubleshooting , we got to know the root cause.

We are sending the AS2 Message in a send port that was running under the 64 Bit host instance.

Reason : AS2 can only work on 32 bit host. It’s one of the known issues in BizTalk due to its ExplorerOM Dependencies

Resolution:

Delete the host instances of that host and change the host setting to 32 bit mode and then recreate the new host instances.

Regards,

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